Background. Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia. In Ghana, severe\nanaemia ismostly due to malaria caused by severe Plasmodium falciparuminfection, road traffic accidents, and haemoglobinopathyinduced\nacute haemolysis. Method. This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD\nenzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana.\nDemographic data and other pertinent information were captured using questionnaire. Sickle cell haemoglobin variants were\ndetermined using cellulose acetate electrophoresis (pH 8.6). Qualitative G6PD status and quantitative G6PD enzyme activity were\ndetermined using methaemoglobin reduction and Trinity Biotech G6PD test kit, respectively. Results. Prevalence of sickle cell trait\n(SCT) and G6PD enzymopathy coinheritance was 7%. In addition, 19.5% of the donors had 10%ââ?¬â??60% of normal G6PD enzyme\nactivity suggesting that these donor units are prone to stressor-induced acute haemolysis when given to recipients. Mild G6PD\nactivity (
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